Santiago Grisolia


August 15, 2022

Santiago Grisolía García (Valencia, Spain, January 6, 1923 - Valencia, August 4, 2022),[1] and Marquis of Grisolía, was a Spanish biochemist.


Born on January 6, 1923 in Valencia, he graduated in Medicine from the University of Valencia in 1944. After obtaining his doctorate in Madrid in 1949, he furthered his studies in the United States at New York University, under the supervision by Severo Ochoa. At this university he began his research on carbon dioxide fixation, a subject on which he continued to work for the rest of his life. He has published more than four hundred scientific papers and around thirty informative articles, also developing an enormous teaching and research work over the course of many years in various European and American countries. Professor of biochemistry and biology at the universities of Kansas, Chicago and Wisconsin, he expands his research on the urea cycle, showing how citrulline is an intermediate in this cycle. He creator and secretary of the Valencian Foundation for Advanced Studies and main promoter of the current Rey Jaime I Awards. He has held various positions, including: President of the Scientific Coordination Committee of the Human Genome Project for UNESCO, Vice President of the Board of Trustees of the Príncipe Felipe Research Center, Advisor to the President of the Generalitat Valenciana for Science and Technology; President of the Valencian Council of Culture since 1996 and the Advisory Councils of the Menéndez y Pelayo International University in Valencia and the Science Museums of Cuenca and Valencia. He was also a member of the European Academy of Sciences and Arts, president of the Valencian Council of Culture, honorary academician of the Royal Academy of Doctors of Spain and founding member of the Free College of Emeritus.

Awards and distinctions

Grand Cross of the Order of Isabella the Catholic (March 2, 2018).[2] Gold Medal for Merit in Research and University Education by the Ministry of Science and Innovation (2010).[2] Prince of Asturias Award for Scientific and Technical Research (1990), together with Salvador Moncada, for his scientific work in the area of ​​biochemistry in very diverse fields, mainly in the enzymology of nitrogen metabolism related to the urea cycle and degradation of pyrimidines.[2] Doctor Honoris Causa by the Universities of Salamanca, Barcelona, ​​Valencia, Madrid, León, UPV, Siena, Florence, Kansas, Las Palmas de Gran Canaria, Polytechnic University of Valencia, University of Lisbon, National University of Distance Education and the University of Castile-La Mancha.[3]


Grisolía, Santiago (2008). Biodiversity. Valencia (Autonomous Community). ISBN 978-84-482-5067-6. Grisolía, Santiago (2007). Climate change and its consequences. Valencia (Autonomous Community). ISBN 978-84-482-4771-3. Grisolía, Santiago (2000). Commitments to the future of the Human Genome Project. BBVA Foundation. ISBN 978-84-95163-37-0. Puigdomenech, Pere; Grisolía, Santiago; Ayala, Francisco J. (2002). Genetics. Book club. ISBN 978-84-226-9669-8. Grisolía, Santiago; Puigdomenech, Pere; Ayala, Francisco J. (2003). Genetics. New Pocket Editions. ISBN 978-84-9759-560-5. Grisolía, Santiago (2006). Bird flu: a health challenge. Editions of the University of Castilla-La Mancha. ISBN 978-84-8427-472-8. Suns, Alberto; Grisolía, Santiago (1988). Severo Ochoa in pictures. Free College of University Emeritus Foundation. ISBN 978-84-404-2060-2. Grisolía, Santiago (2007). Severo Ochoa: a passionate scientist. BBVA Foundation. ISBN 978-84-96515-59-8. Grisolía, Santiago (2001). Transplantation and cloning of human cells in the 21st century. BBVA Foundation. ISBN 978-84-95163-42-4. Sanmartin Esplugues, Jose; Grisolía, James S.; Grisolia, Santiago (200