Bennett, David


January 24, 2022

David Bennett Sr. is the first patient to receive a genetically modified heart xenotransplant. On January 7, 2022, at the age of 57, he received a genome-edited pig heart.


The transplant, led by a team led by cardiothoracic surgeon Bartley Griffith, MD, at the University of Maryland Medical Center in Baltimore, replaced Bennett's heart with a pig heart that had undergone specific gene editing to remove a gene responsible for producing a type of sugar that leads to extremely rapid organ rejection. in people. According to the surgeon, a human heart transplant was not possible due to the patient's medical condition: heart failure and arrhythmias. Bennett received FDA Emergency Clearance to perform surgery under Exceptional Treatment Criteria in a last-ditch effort to cure end-stage heart disease. The transplant was the first heart obtained from a genetically modified pig. Another patient received a kidney transplant from a similar pig in October 2021. Individual porcine heart valves have been successfully used for transplantation for decades.

See also

Baby Faye is the first newborn recipient of a baboon heart transplant. Boyd Rush is the recipient of the first heart transplant from a chimpanzee. Louis Washkansky is the recipient of the first human heart transplant.


Dominic Wilkinson. Pig's heart transplant: was David Bennett the right person to receive groundbreaking surgery? (English). The conversion. Retrieved: 22 January 2022. Talha Burki. Pig-heart transplantation surgeons look to the next steps // The Lancet. - 2022. - January (vol. 399, iss. 10322). — P. 347. — doi:10.1016/S0140-6736(22)00097-6.


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