nicotinamide riboside

Article

July 3, 2022

nicotinamide riboside (Nicotinamide riboside, NR, SR647) is a group of chemical compounds. Pyridine-nucleosides which is a water soluble coenzyme Similar to vitamin B3, it acts as a precursor to nicotinamide adenine dinucleotide, or NAD+.

Chemistry

nicotinamide riboside (nicotinamide β-riboside or N-ribosylnicotinamide) is a riboside converted by the enzyme ribosylnicotinamide kinase. (ribosylnicotinamide kinase; EC 2.7.1.22) is converted to nicotinamide adenine dinucleotide (NAD+) via nicotinamide mononucleotide. (nicotinamide mononucleotide, NMN): ATP + N-ribosylnicotinamide → ADP + NMN

Characteristics

Nicotinamide riboside (NR) was first described in 1944 as the growth factor (Factor V) of Haemophilus influenzae bacteria. Factor V that purifies the blood has been described. In contrast, H. influenzae did not grow in a medium containing nicotinic acid, nicotinamide, tryptophan, or aspartic acid This was previously described as a precursor to NAD+. In 2000 tests on Sir2 yeast showed that NAD+ was dependent on the lysine protein deacetylase. The synthesis of NAD+ in yeast may be carried out via nicotinic acid mononucleotide (NAMN) only if the enzyme that synthesizes NAD+ from the hydrolyzed glutamine in yeast is eliminated. Yeast can still grow in the presence of NR. Subsequently, the conversion of nicotinamide ribosides to NMN was carried out by the enzyme nicotinamide riboside kinase. It gives results in vitro (in vitro) and in vivo (in vivo).

Potential to use

According to a study by the National Center for Biotechnology Information (NCBI), in rats, nicotinamide ribosides can increase the intensity